Gabapentin induces edema, hyperesthesia and scaling in a depressed patient; a diagnostic challenge
Identifieur interne : 001043 ( Main/Exploration ); précédent : 001042; suivant : 001044Gabapentin induces edema, hyperesthesia and scaling in a depressed patient; a diagnostic challenge
Auteurs : Reza Bidaki [Iran] ; Zahra Sadeghi [Iran] ; Safiye Shafizadegan [Iran] ; Ali Sadeghi [Iran] ; Behrang Khalili [Iran] ; Alireza Haghshenas [Iran] ; Seyyed Mohammad Mahdy Mirhosseini [Iran]Source :
- Advanced Biomedical Research [ 2277-9175 ] ; 2016.
Abstract
Gabapentin is a common drug used as analgesic and anticonvulsant and also is prescribed for insomnia, depression, obsessive – compulsive disorder and panic attack. We report a case of a 48-year-old man who is prescribed gabapentin because of insomnia, headache, and depressed mood. In the first period of using the drug no complication has been seen. However in the next period, side-effects such as hyperesthesia, scaling and severe localized edema has been observed. After several laboratory tests and imaging, no reason was found for his edema. And after discontinuing gabapentin the pain and edema was quite relieved. We found out the brand of the drug has been switched in the second stage. The point which makes our study special is the incidence of side-effects such as severe edema, scaling and hyperesthesia for the first time because of using gabapentin and changing the drug combination.
Url:
DOI: 10.4103/2277-9175.174955
PubMed: 26955622
PubMed Central: 4763567
Affiliations:
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a diagnostic challenge</title><author><name sortKey="Bidaki, Reza" sort="Bidaki, Reza" uniqKey="Bidaki R" first="Reza" last="Bidaki">Reza Bidaki</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Psychiatry, Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences, Yazd, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Psychiatry, Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences, Yazd</wicri:regionArea><wicri:noRegion>Yazd</wicri:noRegion></affiliation></author><author><name sortKey="Sadeghi, Zahra" sort="Sadeghi, Zahra" uniqKey="Sadeghi Z" first="Zahra" last="Sadeghi">Zahra Sadeghi</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea><wicri:noRegion>Isfahan</wicri:noRegion></affiliation></author><author><name sortKey="Shafizadegan, Safiye" sort="Shafizadegan, Safiye" uniqKey="Shafizadegan S" first="Safiye" last="Shafizadegan">Safiye Shafizadegan</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea><wicri:noRegion>Isfahan</wicri:noRegion></affiliation></author><author><name sortKey="Sadeghi, Ali" sort="Sadeghi, Ali" uniqKey="Sadeghi A" first="Ali" last="Sadeghi">Ali Sadeghi</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea><wicri:noRegion>Isfahan</wicri:noRegion></affiliation></author><author><name sortKey="Khalili, Behrang" sort="Khalili, Behrang" uniqKey="Khalili B" first="Behrang" last="Khalili">Behrang Khalili</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea><wicri:noRegion>Isfahan</wicri:noRegion></affiliation></author><author><name sortKey="Haghshenas, Alireza" sort="Haghshenas, Alireza" uniqKey="Haghshenas A" first="Alireza" last="Haghshenas">Alireza Haghshenas</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea><wicri:noRegion>Isfahan</wicri:noRegion></affiliation></author><author><name sortKey="Mirhosseini, Seyyed Mohammad Mahdy" sort="Mirhosseini, Seyyed Mohammad Mahdy" uniqKey="Mirhosseini S" first="Seyyed Mohammad Mahdy" last="Mirhosseini">Seyyed Mohammad Mahdy Mirhosseini</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan, Iran</nlm:aff><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan</wicri:regionArea><wicri:noRegion>Isfahan</wicri:noRegion></affiliation></author></analytic><series><title level="j">Advanced Biomedical Research</title><idno type="eISSN">2277-9175</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Gabapentin is a common drug used as analgesic and anticonvulsant and also is prescribed for insomnia, depression, obsessive – compulsive disorder and panic attack. We report a case of a 48-year-old man who is prescribed gabapentin because of insomnia, headache, and depressed mood. In the first period of using the drug no complication has been seen. However in the next period, side-effects such as hyperesthesia, scaling and severe localized edema has been observed. After several laboratory tests and imaging, no reason was found for his edema. And after discontinuing gabapentin the pain and edema was quite relieved. We found out the brand of the drug has been switched in the second stage. The point which makes our study special is the incidence of side-effects such as severe edema, scaling and hyperesthesia for the first time because of using gabapentin and changing the drug combination.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cavanna, Ae" uniqKey="Cavanna A">AE Cavanna</name></author><author><name sortKey="Ali, F" uniqKey="Ali F">F Ali</name></author><author><name sortKey="Rickards, He" uniqKey="Rickards H">HE Rickards</name></author><author><name sortKey="Mccorry, D" uniqKey="Mccorry D">D McCorry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mathew, Nt" uniqKey="Mathew N">NT Mathew</name></author><author><name sortKey="Rapoport, A" uniqKey="Rapoport A">A Rapoport</name></author><author><name sortKey="Saper, J" uniqKey="Saper J">J Saper</name></author><author><name sortKey="Magnus, L" uniqKey="Magnus L">L Magnus</name></author><author><name sortKey="Klapper, J" 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